Yeah DrGuile. I know it's kind of cliche, but I live 10 minutes away and these places never get old:
Empire State Building
Times Square, (there's a zillion things always going on there!)
Broadway/6th Ave. Stores
Rockefeller Center
NBC studios (across Rockefeller) is pretty cool, you might even be able to walk-in to a showing of the Conan O'Brien show at around 4:30 PM.
And as somebody previously mentioned, for nightlife/restaurants, you might want to check out the part of Manhattan that is commonly referred to as "The Village". Anyway, enjoy your trip!
