JQUERY I'd say allows you to do the most...
Apart from that it doesn't really matter what you use... php, .net, blah blah... can make anything do what you want.
Newest project we're working on is still using SQL Server 2012, Visual Studio 2010, is done in vb.net. All that is being displayed to a visitor is pure HTML and JQUERY.
Site is 100% fully responsive, is faster than pretty much anything out there and scores 95-100% on all speed tests and platform tests.
Just use what you're used to, there's always a way to adapt it to whatever the newest trends are
