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Originally Posted by Harmon
Does this have anything to do with sickle cell anemia?
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Kind of. Since the liver filters the blood, and is very vascular, sickle cell may eventually cause liver complications such as acute liver failure. However sickle cell is a genetic trait, not a symptom of an unhealthy liver. The good news for those with sickle cell though is that they have a natural resistance to malaria, which is likely why it is more common in those of African descent.