In regards to what?
Are you mailing GI and trying to clean out traps?
If you're mailing current lists, you should be able to clean out complaints, unsubscribes and bounces fairly easily as long as you have FBL's set up for the different TLD's all depending on your MTA... assuming you're using one versus an ESP solution like Amazon.
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Should You Email Your Members?
Link1 | Link2 | Link3
Enough Said. 
"Would you rather live like a king for a year or like a prince forever?"
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