We used a 1511 with WD Caviar Black's for years and it was great. Most things are migrated to our EMC pool now since we've got a pipe direct to the rack from our office, but the Synology still runs and gets used because it's just damn convenient.
That said, I'd take a serious look at commercially-supported FreeNAS and Openfiler builds. the iXsystems once that directly support FreeNAS are really nice and you'll have worlds more power if you want to do anything fancy.
Another thing, stay away from the tiny consumer appliances that cram <5 drives directly against every heat source they can find. If there's not a little breathing room you're going to have a bad time. (Most <5 disk Synologys and other big brands have tons of complaints about this.)
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