With mobile homes you typically pay "lot rent" in addition to your mortgage and insurance. Meaning you have to rent the lot your mobile home sits on, so in Silicon Valley, this might be high. Check it. Since the park also has amenities, like pool, etc., there may also be fees for that, similar to condo fees. There are also California taxes:
http://www.co.santa-cruz.ca.us/tax/mobpam.htm
but you'd be paying taxes on a house in California regardless of what you buy.
Remember in California you pay 13.3% of your income as income tax and 1% for SDI (State Disability Insurance). If you're moving from Florida, you're immediately giving up 14.3% of your income.
Also, mobile homes can drop in value precipitously, they're considered "vehicles" not real homes.
All that aside, if it's a better place for your career, and you don't mind the taxes and additional expenses and the whole "living in a trailer park" lifestyle...