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We use Zimbra which has a decent AI anti spam system built in and also uses a couple of large DNSBLs which I can configure. We get tons of spam but only 2 or 3 per month manage to get through the filters and once they are flagged the same senders rarely get through again. (And those only get through thanks to having common / well known default addresses for hosting businesses which have to be advertised).
The only issue w/ using Barracuda is the amount of false positives, they block just about everything and have a very poor removal record.
You could use a white list service where senders are required to verify themselves and you are required to approve them. I do something like this to manage my gmail account which attracts tons of spam as will any popular free webmail service.
Making sure your email address is not posted online is the first step but that's not always possible beyond taking steps to try and prevent email scrapers from picking it up easily.
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-= Software / Systems Architect and Server Geek =-
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