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It's related to the aperture, the smaller the aperture the bigger the depth of field. So for most it\s related to the amount of light you have. Shoot indoors at F11 or smaller and it should be fine, unless it's indoors in a big barn. Shoot at F32 and it shod all be fin3e, but the flash might blind everyone. LOL
Outdoors you're controlled by the available light, the sun. Or you need to get power for your strobes. Simon's reply was good.
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