First trick is not use only adsense... Then any theme that isn't locked around a design will work. Like the twentyten theme has plenty of space below the main menu and footer, it's easy enough to slip in ads above/below/within posts... Just make your ad menus look like the site, and your set... and select different templates that have various sidebars, that way you can test the style and use the one that works the best.
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