It's hard to pinpoint "one" single movie...
2001: A Space Odyssey or The Matrix would probably take my top vote. But....
Blade Runner
Soylent Green
Altered States
Close Encounters of the Third Kind
Phase IV
Silent Running
Planet of the Apes
A Clockwork Orange
Star Wars (though not strictly science fiction)
Forbidden Planet
Metropolis
They Live
Invasion of the Body Snatchers
The Time Machine
The Fly
Robocop
Starship Troopers
Terminator
Alien
Aliens
The Invasion
Pitch Black
John Carpenter's The Thing
Enemy Mine
The Lathe Of Heaven (tv movie)
Dark City
The War Of The Worlds (both versions)
Minority Report
Gataca
The Brood
The Omega Man
The Day of the Triffids
Logan's Run
The Road Warrior
The New Star Trek, Star Trek: The Motion Picture (plus Wrath Of Khan and The Voyage Home)
... are all seminal in one way or another. And I'm probably forgetting a bunch, that don't even "seem" like sci-fi like Back to the Future but which actually follow principles very nicely...
You could even say movies like 28 Days
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