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If you're a proper web developer you should be using all of the browsers you can get your hands on; and regularly. The only one I don't use is Safari on a Mac, because I don't use Mac (I am buying one because I think it's important for my mainstream sites too and their audio productions suite is pretty awesome - even though I think a lot of Mac users are wanks).
IE is the base browser that most of your surfers use before they become aware of the other ones... until they get told about a better browser, which is often years, they're going to use the stock out-of-the-box software... often not even updated with patches etc.
You should always build your sites to work on at least IE, Firefox, Opera and Chrome. I have never found any issues with compliance or a work around for any problem in my development.
Speaking of which I'm going to start offering a help page on my sites for surfers to get the latest in browsers, codecs and other such related software.
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