From your profile on gfy I have no idea who you are. So if some affiliate programs that you belong to are spamming you...it's more than likely a script doing it. And if you are completely incognito on gfy then a real person from that program wouldn't know who to put on the opt out list anyway.
Maybe you should identify yourself or at least give someone a hint of who or what you are in the business
I know that I LIKE getting offers to make money with my traffic and make sure that everybody knows what I do.