My favorite place to stay is the Venetian
You've got Tao right downstairs too if that's your sorta thing...
If you're looking for party hotels though your best bet are the Palms and the Hard Rock, both of which are off strip... Everything is a quick cab ride away though so what's the big deal?
edit: Forgot about planet hollywood, one of my favorite places to hang out but I've never stayed there, maybe worth a look.