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Like many have pointed out, impossible to say 100% what would happen: Mike's fist vs. MMA fighter's takedown. But keep in mind today's elite MMA guys are very good with their fists as well as avoiding being hit so I'd think they would have little trouble avoiding his punches long enough to get him to the ground ... and then it's lights out Mikey.
Also, Mike trains for guys standing right in front of him, fists only. An MMA guy could keep him off balance with leg kicks long enough to grab him. Again, lights out Mikey. (Or in Mirko's case, for example, the kicks would end it quickly)
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