I work on Saturdays regularly and am available to any affiliate who needs me, but if you go straight through life without unplugging from the grind regularly, you're doing yourself, and those in your life, a disservice.
And, with rare exceptions (for which companies such as the one I work for have protocols in place to handle), what's so important that it can't hold a few hours or couple of days anyways? With all due respect, maybe it's your ability to manage time effectively that needs an overhaul.
In anology: there's always a market open somewhere in the world - yet banks still close.