What the hell... I'll take a stab at this (only because I a similar conversation with my 13-year-old son the other week)
Niche - I studied French in high school, so I started out saying "neesh". However, I've been trained out of it in speaking with other webmasters. Nowadays it sounds more like "bitch" or "rich".
MPEG - Em-peg
JPEG - Jay-peg
GIF - like "gift" without the "t" on the end (The hard "g" here makes it easier to differentiate between the pic types in conversation)
ISPrime - eye ess prime
Epoch - like epic (what the hell is an EE-pock anyway? LOL)
Equinox - I've always said "EE-qui-nox"; forgive me if I've mispronounced you
Like Whoa - "like woe"
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