Buffalo rocks!
Bison is a red meat that is about 70% leaner than your normal cow burger, 50% less cholesterol, 30% higher in protein with no known human allergies, and no problems with E-Coli in Buffalo.
Its a sweeter meat, Lycanthrope is right about what goes best with one, but I find everything tastes better with Bison. Also if you want an excellent first impression with bison meat, find a
Ted's Montana Grill by you.