I don't know a damn thing about Zoloft, but if it's a choice between a manmade drug and a natural plant go with the weed.
No need to smoke, either, if you grab a vaporizer. Heats up the herbs to a temperature that vaporizes the THC and doesn't burn the unneeded plant material. Smoke free.
I use a volcano vaporizer, they're fucking great. I'm gonna spam you with a reflink, but know that I'd recommend it reflink or not, I use the thing every day. I used it exclusively for a while and started feeling a lot better, but I can't give up the blunts.
http://www.gotvape.com/idevaffiliate...p?id=167_6_3_9