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mysql_query("UPDATE [yourtablename] SET wp_user = '".mysql_real_escape_string(trim($_POST['username']))."'");
That will do the trick. It will fill every wp_user in the table with your POST value. If that is not what you want, you will have to specify a condition using WHERE.
For example:
mysql_query("UPDATE [yourtablename] SET wp_user = '".mysql_real_escape_string(trim($_POST['username']))."' WHERE wp_id = 1");
The function mysql_real_escape_string and trim are not necessary, but they add some extra flexibility and security.
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