If you're looking to send large volumes of mail I've got a program for campaign management. Starts at $9,975 and scales up as you add more mail servers. Most of the features are not really useful to blatant spammers though, no proxies, no relays, no IP changing/spoofing, etc. But if you've got legit email and you want to determine country, get opener/click counts, etc. check out
http://www.humaniq.com/mailcluster