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I'm using it with qmail and it works great. I don't get too many false positives, and the one's I do get are mostly sponsor newsletters. My overall threshold is set at 2.0. I have some custom rules/filters setup that I've been tweaking for a while so as time goes by it gets better and better so that helps. That, and the bayesian filters.
I also use ClamAV which also works well.
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