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Common sense. I've never had an infection, and since I stopped using I.E. except to ensure my shit still works with it, I've not had a nasty popup problem.
NAV Corp is decent, but man, SpyBot's been shit since the v1.3 days; I'd suggest you use Ad-Aware if you actually have issues with popups.
NOD32 is probably the best AV I've used on a small-office basis, following that, AntiVir, and AVG. Avast is too resource-polluting and likes to force you to reboot; Microsoft will probably buy them for that reason alone.
Microsoft's 'Defender' is actually pretty useful as an anti-spyware tool (Beta 1 was awful, even if it was just GIANT with a facelift).
In conclusion: Pie is good. Eat more pie.
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