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The spider's venom contains an enzyme that destroys cell membranes in the wound area with affected tissue gradually sloughing away, exposing underlying tissues. Within 24 hours, the bite site can erupt into a "volcano lesion" (a hole in the flesh due to damaged, gangrenous tissue).
The open wound may range from the size of an adult's thumbnail to the span of a hand. The sunken, ulcerating sore may heal slowly up to 6 to 8 weeks. Full recovery may take several months and scarring may remain. Plastic surgery and skin grafts are sometimes required.
