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DivX is best for those on a shoestring budget on a site when it comes to size-to-quality ratio. Even though the mass majority of people will have it on their computers you will have the one or two fucks who are clueless about it, but if you are on a tight budget it may be necessary to sacrifice that 3-5% of people. WMV for safety reasons I guess. MPG/MOV, I would say no for a couple of reasons (MPG because of size-to-quality ratio sucks hardcore, MOV because I would think more people wouldn?t have a player capable of playing MOV?s than DivX). I would go with WMV + MOV I guess for great compatibility.
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